Locations regarded as most desirable today might not keep that status forever, but they're good models to use when you're searching for a home.
Why are those neighborhoods in demand and how long have they been top choices?
Are there other areas in town that are increasing in desirability?
Does new growth in town seem to be headed towards a certain area? Will there be plenty of services (groceries, shopping, schools) in that area?
Is the community changing--with residential areas shifting over to commercial properties? (That can sometimes be a plus for eventual value, but a negative while you live there.)